Isaac married Sarah HARRINGTON on 17 Aug 1777 in New York, USA. Sarah was born on 28 Jun 1750 in Warwick, Kent, Rhode Island, USA; died on 14 Oct 1762 in Little Compton, Newport, Rhode Island, USA. [Group Sheet] [Family Chart]

1. Phoebe Alma OSTRANDER was born on 25 Jun 1782 in Albany, New York, USA; died on 21 Nov 1846 in South Marysburgh Twp, Prince Edward County, Ontario, Canada.
2. Jemima OSTRANDER was born on 12 Feb 1777 in Rensselaer, Rensselaer, New York, USA; died on 7 Sep 1859 in Ameliasburgh Twp, Prince Edward County, Ontario, Canada.
3. Samuel OSTRANDER was born on 18 Jan 1783 in Brunswick, Rensselaer, New York, United States; died on 9 Dec 1864.
4. Lydia OSTRANDER was born on 21 May 1794 in Adolphustown, Lennox and Addington County, Ontario, Canada; died on 29 Nov 1872 in South Bay, Athol Twp, Prince Edward County, Ontario, Canada.